Cereblon as a Predictive Biomarker for Imid Therapy Sensitivity
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چکیده
منابع مشابه
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity
Cereblon, a member of the cullin 4 ring ligase complex (CRL4), is the molecular target of the immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide and is required for the antiproliferative activity of these agents in multiple myeloma (MM) and immunomodulatory activity in T cells. Cereblon's central role as a target of lenalidomide and pomalidomide suggests potential utility as a predict...
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ژورنال
عنوان ژورنال: Journal of Hematology & Thromboembolic Diseases
سال: 2014
ISSN: 2329-8790
DOI: 10.4172/2329-8790.1000e112